Newcastle disease virus and immunity – an effective alliance in the fight against cancer (literature review)

Currently, cancer remains one of the leading causes of death in the developed world. The use of oncolytic viruses (OS) is a promising possible method for inhibiting tumor growth. Despite the fact that the discovery of the oncolytic function of a number of viruses took place in the last century, the use of OS has not yet found proper recognition.

Some of the most promising are viruses of the Paramyxoviridae family, in particular the Newcastle disease virus (NDV), which is not pathogenic for humans and has some effective mechanisms of affecting tumor cells and inducing an immune response. NDV is characterized by selective infection and spread of the virus in tumor cells, a direct cytopathic effect, as well as indirect induction of the innate and adaptive immune response of the host. However, intratumoral administration of OM is not always possible and leads only to local action.

There is an assumption that the cells of the immune system can be used as possible carriers of OM to provide temporary protection against the factors of the immune system of the tumor-bearing organism. Dendritic cells (DCs) were the most effective cell carriers among the many types of immune cells assessed in studies of the effect of OM. Thus https://de.the-celebrities.site/page-animal-planet-wie-tia-torres-pitbulls-and-parolees-the-vil-ins-leben-gerufen-hat, the combined action of OM and DHQ is important for the mutual potentiation of the antitumor effect of both components (viral and cellular); obtaining such products seems to be advisable with

the purpose of their further clinical use.

Keywords.

About the authors.

Sitkovskaya Anastasia Olegovna – Junior Researcher, Laboratory for Immunophenotyping of Tumors.

Rostov-on-Don, 344037, st. 14th line, 63.

SPIN: 1659-6976, ResearcherlD (WOS): E-7496-2018, Author ID (Scopus): 56381527400.

Zlatnik Elena Yurievna – Doctor of Medical Sciences, Professor, Chief Researcher of the Laboratory for Immunophenotyping of Tumors.

Rostov-on-Don, 344037, st. 14th line, 63.

SPIN: 4137-7410, Author ID (Scopus): 6603160432.

Novikova Inna Arnoldovna – Candidate of Medical Sciences, Leading Researcher of the Laboratory for Immunophenotyping of Tumors.

Rostov-on-Don, 344037, st. 14th line, 63.

SPIN: 4810-2424, ResearcherID (WOS): E-7710-2018, Author ID (Scopus): 7005153343.

Kit Oleg Ivanovich – Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, General Director.